For the painting:
Anime & Manga- JoJo's Bizarre Adventure: Stone Ocean: Under the effects of Bohemian Rhapsody, a police officer is turned into the Girl with a Pearl Earring, while her coworker is turned into Heracles.
- Komi Can't Communicate: The splash page for Chapter 283 depicts Komi as the Girl with a Pearl Earring.
Literature
- The Medusa Frequency:
- The cover art is the Girl with a Pearl Earring if she was a gorgon with snakes for hair.
- Herman Orff, The Protagonist, is a tad obsessed with this painting.
Live-Action TV
- America's Next Top Model: In Cycle 5, when there were five contestants left, the challenge was to recreate a classic work of art, one of which was the painting.
- The Chase (Game Show): The 2020 Christmas Episode had the Chasers dress up as subjects from famous paintings, including this one and The Mona Lisa.
Music
- GFRIEND: The music video of "Sunny Summer" has one of the girls dress and pose like the painting. A few seconds later, the painting itself is shown.
Video Games
- Animal Crossing: From Animal Crossing: City Folk onward, the player can obtain a copy of Girl with a Pearl Earring as the Wistful Painting, one of many pieces of art that can be donated to the museum. In Animal Crossing: New Leaf, forged copies can be identified by the girl's headband being orange instead of blue, while in Animal Crossing: New Horizons, fakes bear a star-shaped earring and occasionally blink.
- Criminal Case: Mysteries of the Past: In The Victim's Vault scene of "Case 37: Death Comes to Lunch", there is a satirical version of this artwork.
Western Animation
- We Bare Bears: In "Panda's Art", Panda tries to reproduce his first painting of Charlie by drawing in the style of many classic paintings such as Vincent van Gogh's self-portrait, Girl with a Pearl Earring, The Scream, and The Son of Man.
- WordGirl: In "Two-Brain Highway", the painting can be seen in the back of the museum's rare cheese exhibit, with a little twist: her face is a roll of cheese.