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- =3: Reviewed the latest Viral Videos. Retired.
- The 8-Bit Guy
- 10 Things Webkinz Do: Sketch comedy series starring Webkinz plushies.
- 3DBotMaker: Diecast toy car racing channel run by American diecast toy car enthusiast and track accessory maker Adriel Johnson.
- 3kliksphilip: Group of channels under one name hosted by Philip Dyer. 3kliksphilip analyses CS:GO, 2kliksphilip analyses real life, and kliksphilip has assorted content.
- 5 Seconds of Summer: The Band Upload the music cover to get famous.
A
- Abroad In Japan: Chris Broad, a British ex-pat living in Japan since 2012. His videos focus on Japanese culture, food, and travel, primarily in the Tōhoku region.
- Absurdlyawesome
- Adeptus Ridiculous
- Addison Rae
- Ahoy
- Akfamilyhome
- Alan Becker
- Alex Day
- Alex's Corner
- All About Meep: Skit videos starring American Girls and Lalaloopsy dolls.
- Alessia Cara
- Allie Goertz
- Allison Pregler
- Ally Hills
- Alonzo Lerone
- AlphaOmegaSin
- Alpharad
- Alpharad Goldnote
- Amanda Lee: Known as "leeandlie". Does English covers of anime songs.
- Phil Lester, also known as AmazingPhil
- Ami Yamato: An early virtual vlogger. She posts videos about her life in London and Japan, and inserts herself into movies and TV shows using clever editing.
- Andre the Black Nerd: Humorous videos where he talks about movies and TV series.
- Andrew Bachelor: Also known as "King Bach".
- Andrew Bowser
- The Anime Man
- Anna Akana: Short Film Maker and actress. Also life advice comedy.
- Anna Brisbin: Known on YouTube as Brizzy Voices. Voice actress, voice impressionist and avid gamer.
- Angelica: Deranged and/or bizarre fake ASMR.
- Animals Rule
- The Annoying Orange, whose first video al-Nye-heh-heh-heh-heh-one has more than 90 mil-Nye-heh-heh-heh-heh-lion views. It had a major television deal with Cartoon Network and premiered its TV show The High Fructose Adventures of Annoying Orange in summer 2012 and ended in May 2014.
- The Angry Video Game Nerd started off on YouTube in 2006 before moving to ScrewAttack after his videos started becoming more popular.
- Animal Wonders, a show centered around the Missoula, Montana-based educational wildlife facility of the same name. The host, Jessi Knudsen-Castañeda, gained YouTube notoriety for her appearances with animal guests on SciShow.
- Another Dead Hero: A bad comics, movies and anime review channel hosted by James Carlson.
- Ariel Versace
- Ariana Grande
- Ariota 4291
- Arlo
- Ask A Mortician: Mortician Catilin Doughty explores our relationship with death.
- Athena P
- Atun-Shei Films: Independent filmmaker and historian best known for Checkmate, Lincolnites!.
- Aunty Donna: Hugely successful Australian absurdist comedy group.
- Austin St. John (former Power Rangers actor who also vlogs and creates fan-related content).
- Azenzone: Japanese-Hawaiian content reviewer, usually focuses on shows created by Toei Company and Toei Animation.
B
- Bad Lip Reading
- Balena Productions: 3D animation best known for his Sonic content like Christmas With Sonic and Sonic Zombie
- El Bananero: Uruguayan comedian of Toilet Humor and Sex Comedy. His success made him the Trope Codifier and an inspiration for Latin America Youtubers.
- Be Amazed
- Baumgartner Restoration: Julian Baumgartner, art conservator based in Chicago, restores paintings.
- Bento Banana: A Sci-Fi Dark Comedy series that parodies anime tropes.
- Jill Bearup
- Bedtime Stories (YouTube Channel)
- Behzinga: Co-founder of the Sidemen.
- Bernadette Banner
- Bible Illustrated
- BigStackD Casting
- Bill And Doug: A.k.a RVDTito4Life). Hosts of TNA Addicts.
- bill wurtz
- Billy Coore
- Bishop Barron: Movie reviewer, Bob Dylan fanatic, preacher.
- Black Gryph0n: voice impressions and song covers as well as original music and vlogs.
- Black Mage Benjamin
- Black Rhino Ranger: Animated shorts.
- Blanks
- Blixemi: A YouTuber who makes animated shorts and songs based around Warrior Cats
- Bo Burnham.
- Bob Chipman
- Boogie2988
- BotanicSage: Mashup musician.
- Boyce Avenue: Mostly does acoustic covers, though they do have original songs.
- The Brain Scoop: Animal science, ecology and taxidermy, hosted out of the University of Montana's Philip L. Wright Zoological museum and later the Chicago Field Museum, by Emily Graslie.
- Brandon Rogers
- Brendan Blaber
- Brian Hazen
- Brian Hull: Voice actor, voice impressionist, and Disney fan.
- Bricky: Videogame reviewer, streamer and diehard Warhammer 40,000 fanboy.
- BryanCroiDragon: Lets player, streamer and audio book reader.
- BSL's Reaction Asylum
- Bumbles McFumbles
C
- Caddicarus
- CalebCity
- Caleb Hammer
- Caleb Hyles: Mostly does rock covers, though he does have original songs.
- Calfreezy
- Call Me Carson
- C&Rsenal
- Captain Disillusion
- Captain Southbird
- The Cartoon Chronicles Of Conroy Cat: It began as a Webcomic before being a Web Animation series on YouTube.
- Casual Geographic
- Cas van de Pol
- CDawgVA
- CG5
- CGP Grey
- Chad Chad
- The Chalkeaters
- Charity Shop Sue: Scripted Mockumentary sitcom.
- Charli D'Amelio: Dancer. Vlogger on YouTube and most followed creator on TikTok
- Charlie Is So Cool Like: Dyed her whole body purple and singing.
- Charlie the Unicorn: Originates from Newgrounds). 40+ million views.
- Charmx: YouTube reaction channel.
- Chibi Maruko-chan (the English dub is a YouTube original)
- Justin Chon
- Chonny Jash
- Chris Fleming
- Chris Ray Gun: Political commentary, parodies, and original music.
- Chris Stuckmann
- Christina Grimmie: Began her career by posting piano/vocal covers on YouTube, under the username "zeldaxlove64". Expanded her content to include a series of deliberately over-Autotuned music humor videos with friends of hers on her account under the title, "Above All That Is Random" . Also hosted a series of video game reviews for Disney on their short-lived "disneysgames" channel titled "Power Up With Christina Grimmie" in 2012. Sadly was murdered by a crazed fan at a post-concert meet-and-greet event in 2016.
- Cimoooooooo
- City Nerd
- Coji-Coji
- Cr1TiKaL
- Chuggaaconroy
- Chloe x Halle
- CJ DaChamp
- Climate Town
- ColeyDoesThings: Short skits commenting (comedically) about various fandoms and fan work tropes.
- ComedyShortsGamer
- ComicTropes
- Community Channel: Australian woman Natalie Tran, got her own TV spot as a result of her internet popularity.
- ContraPoints: Political and cultural analysis, silly costumes, lots of drinking.
- Corgipon: Originally known as VanillaFlare, her videos cover topics about the British Royal Family (more specifically, the Queen Elizabeth II), her original series Britsune Garden, and Nihonverse, her AU of Puppy in My Pocket: Adventures in Pocketville.
- Corpse Husband: A recording artist, horror story narrator, and gamer, knowing for his "infrasonic bass".
- Cory Williams
- CoryxKenshin
- Count Dankula
- Crank Lucas
- Crash Course: Vlogbrothers' Edutainment. Hank covers science topics, while John covers the humanities.
- Cristina Valenzuela: Known as "CristinaVee". Does anime covers.
- Cutie Pie Marzia: PewDiePie's wife.
- The Cynical Brit
- Cynical Reviews
D
- Daily Grace: A five days a week comedy show hosted and edited by Grace Helbig.
- D'Angelo Wallace: Commentary videos. Most viewed video features the downfall of Shane Dawson.
- DanTDM: One of the most well-known Minecraft-based content creators of the early- to mid-2010s.
- Dan and Phil: Duo
- Daniel Thrasher
- Danny Gonzalez: Commentary videos and parody songs.
- DarkMatter2525
- Dark Secrets of Garry's Mod
- Dave Days began as a Youtube musician, and still makes videos.
- David Dobrik: Leader of the Vlog Squad, known for their comedy and vlogging videos.
- David Near: Does voice impressions of horror characters and more.
- Davuu Wart
- Day9
- Desolo Zantas
- Dhar Mann
- Diamanda Hagan: Best known for her Bonekickers reviews.
- Diamondbolt
- Doctor Steel: Propaganda and music. namechecked by several media outlets and shows, including Jay Leno and MTV.
- Docudubery
- doddleoddle
- Domics
- Doobus Goobus
- A Dose of Buckley: Although Adam Buckley insists that he's not a YouTuber, instead referring to himself as a rant comedian and social commentator who uses YouTube as as his content delivery system.
- DougDoug
- D Piddy
- Dr. Pimple Popper: Started out as the YouTube channel of Southern California dermatologist Sandra Lee before spawning the current TLC series of the same title. Dr. Lee still regularly posts content to her YouTube channel.
- Drachinifel: British engineer and amateur naval historian, noted for his sarcastic humor.
- Drew Gooden
- Dross Rotzank: Latin American with horror, conspiracies and morbid humor. He was a blogger who focused on comedy with a character.
- Drunk History
- Dubbed By Strangers: Canadian television reviewers.
- Dude Perfect
- Duma Ragu
- Dua Lipa: Pop Singer and Songwriting as being her career she bening upload a video a cover artists to make famous on YouTube, to became a YouTuber,
- Durendal
E
- Eat Your Kimchi
- Economy Watch
- Eddie at The LMV
- Edward Current, an atheist vlogger and humorist who plays a rather extreme Christian character.
- Emma Blackery
- English by Stéaviñ
- Epic Meal Time
- Epic Rap Battles of History, a comedy series where historical and fictional characters face off against each other in Battle Rapping.
- Eric Calderone
- Evan Erwin: aka "mrorangeguy", hosts The Magic Show, about Magic: The Gathering.
- Everyman HYBRID
- ExoParadigmGamer
- Exploring With Josh
F
- Failboat
- FailRace
- False Swipe Gaming
- Fascinating Horror
- Fawful's Minion
- Featureman
- Feeding Steven
- Folding Ideas
- Forgotten Weapons
- Formula 1
- The Fourth Age Makes long videos about the state of comic books and compares them to philosophy.
- Frank Jav Cee
- Fred
- Freddie Wong: Creating amazingly high-quality special effect videos with just amateur equipment and budgeting.
- Fredo On TV
- FreedomToons
- French Baguette Intelligence: A channel that makes Ace Attorney parodies based on Discord conversations.
- Freshy Kanal
- Filthy Frank: Former channel and YouTuber persona of George "Joji" Miller
- The Foxy Bard
- Furious Pete
- Furry Found Footage: Retro themed furry media reviews.
G
- Gabbie Hanna: Originally known as The Gabbie Show.
- Game Grumps: Two internet personalities play games together, occasionally paying attention to what they are doing. Much hamming and Seinfeldian Conversation ensues.
- GaMetal
- GameToons: A channel by Newscape Studios starring a casual gamer who Lampshades logic in video games every chance he gets.
- generic purple protogen
- ghosttundra
- Gia Gunn
- Gigguk
- Ginny Di
- Gobelins
- GGB 123: The creator of Algicosathlon Camp.
- Sofia Gomez
- Grace Helbig: Known for her eponymous comedy sketch show, It'sGrace.
- GradeAUnderA
- Grav3yardgirl
- Grazyna Zarko
- The Gregory Brothers
- Gus Johnson
H
- h3h3productions
- Habitual Line Crosser
- HalaCG
- The Happy Spaceman
- Harvey Rothman
- Joel Haver
- H.Bomberguy: think pieces on gaming and leftist politics, the latter more humorous than the former and mostly mocking far-right content creators and debunking scientifically wrong views associated mostly with the right, like climate change denialism and Flat Earth.
- HELLWINKLE: Comedy series using Care Bears plushies.
- Henry's Kitchen
- hololive
- Hollywill 06 She is the creator of Brawl For Fantasy World
- Hollywood News Agency
- Horror Shorts Party
- Daniel Howell, previously known as Danisnotonfire
- Huggbees
- Husky Starcraft
- Hyce
I
J
- Jacksfilms: Skits, parodies, and audience reactions-based series.
- Jack Serra
- Jack Spero
- Jackson Lennon
- Jack Rackam
- Jacob Geller
- Jacob M. Keene
- JaidenAnimations
- Jake Paul: Originally popular on Vine. Known for prank videos, music career and his boxing career. Younger brother of Logan Paul.
- JAMIEvstheVOID: active as a storytime animator from 2016-2022, now a vlogger. Did a video credited with raising awareness of aphantasia.
- James Charles: Make-up artist and influencer. Known for his make-up tutorials, reviews and the (in)famous Dramaggedon scandal in 2018.
- James Lee
- James Rolfe
- Jandrew Edits
- jan Misali
- Jarvis Johnson
- Jason Nash: Member of the Vlog Squad. Dated Trisha Paytas.
- Jaymes Mansfield
- Jeffree Star: Former MySpace celebrity, music artist and owner of Jeffree Star Cosmetics. Known for his flamboyant style and his many scandals and feuds.
- Jenna Marbles: Former pinup model with a master's degree does comedy and rants, frequently at the same time.
- Jenna Moreci: Produces videos centered around creative writing advice.
- JENSAARAI 1
- Jeremy Chinshue: Animates video game parodies as TerminalMontage
- Jerma985: Variety streamer on Twitch, uploads his stream highlights to YouTube
- Jesse Cox
- Jessi Smiles: Popular comedic skits from Vine. Also known for her make-up 'Get Ready With Me' videos.
- Jessie Gender: A Transgender Youtuber who specializes in reviews of Star Trek and political videos, usually about LGBTQ+ and neurodivergent issues.
- Jet Lag: The Game: 3-4 players complete assorted challenges in a travel-based competition.
- Jim Browning: Serious-ish scambaiter of Indian call centre fraudsters.
- Jimquisition: A show by Jim Sterling which specializes in pointing out failures, issues, and abuses in the Video Game Industry.
- JimmyHere
- Jimmy Tatro
- The Joker Blogs: Post-Dark Knight series that chronicle the Joker's time in Arkham Asylum.
- JonTron
- Jonathan Young: Mostly does rock covers, though he does have original songs.
- Joseph's Machines: Creates Rube Goldberg Devices.
- Joueur du Grenier: Reviewer of bad retro video games and bad licenced games.
- The Juice Media: Australian company producing political leftist satire.
- Juno Songs
- Jreg: A (mostly) political satirist, best known for his Centricide series featuring political ideologies as characters.
- Just Art
- Justin Bieber: Began his career when he and his mother posted homemade videos of himself on YouTube,here.
- Just Vidman
K
- Kaguya Luna
- Kanako Urai: Host and creator of KanaChanTV, a cooking and lifestyle (as well as occasional gaming) channel.
- Karameru
- Katya
- Katzun
- The Keef Crew: Mighty Keef, a video game and anime enthusiast, who often makes comedic videos and parodies surrounding video games — in particular, the Fighting Game Community.
- Jessica Kellgren-Fozard
- Ken Ashcorp: Musician of the nerdy variety. Started on YouTube under his then-alias, foreverpandering, before eventually shifting to a newer channel under his real name.
- Gus Kenworthy
- Kicesie does non-graphic sex education videos.
- KickThePJ
- Kiwami Japan creates knives out of unusual materials.
- Kizuna AI
- KSI: One of the UK's most popular YouTubers, starting out with video game commentary before expanding into other ventures including rapping and boxing. Also co-founded the popular group the Sidemen.
- Kurtis Conner does comedic commentary.
- Kyle Allen Music
- Kyle Exum
L
- Laci Green, host of the show Sex+ and a popular sex educator. Similar to one-woman sketch comedy.
- Lasagna Cat
- Lady Emily
- Laura Lee: make-up guru and (in)famous for her rubbish apology video.
- Lawrence Rose: host of Lawrie's Mechanical Marvels.
- LDShadowLady: A Let's Player famous for playing Minecraft.
- LegalEagle: A lawyer who makes videos about laws portrayed in media.
- Legend57 Rap Battles
- Lele Pons: Originally the most viewed creator from Vine. Known for her comedic videos.
- LGR: Formerly known as Lazy Game Reviews, Clint Basinger focuses on vintage computing, mostly MS-DOS games and obscure hardware.
- Lia Marie Johnson: Mostly makes original songs plus the occasional comedy sketches.
- Life of Luxury
- LilyPichu
- Lily Orchard
- Lindsay Ellis started her YouTube career as the Nostalgia Chick, the Distaff Counterpart of The Nostalgia Critic, but she distanced herself from that show (seeing it as an Old Shame) and runs her own channel now with more serious film analyses.
- Lindsey Stirling: Violinist and dancer who does musical content and collaborations in her channel.
- theLittleFears
- LittleKuriboh
- Linfamy: Teaches Japanese history and folklore.
- lonelygirl15, which gained massive media recognition for being one of the first scripted web series to reach a mass audience (the first ever web series with an ongoing plot and real, professional actors was The Spot, which debuted in 1995). It codified most of the tropes seen in later vlog-driven series. It initially being mistaken for an actual, non-fiction vlog also earned it publicity early on.
- LongBeachGriffy
- Logan Paul: Popular creator originally from Vine. Known for his energetic vlogs, prank videos and various scandals. Also has a popular podcast and a boxing career.
- Lock Picking Lawyer, Picks locks and shows history of old historical locks.
- Lord Wojak: Makes stories involving the Wojak meme as the main character.
- LowTierGod: An infamous videogame player, mostly associated with fighting games, who celebrates himself for rage quitting on the justification that every player online is bad except himself, believing that humans are a failed creation made by god-like aliens, claiming that he is a living deity and "perfect specimen" based on his looks and beliefs, and banning anyone who disagrees with his actions or views while giving detailed descriptions about sexual encounters with their mother—amongst many other things.
- LS Mark
- Luisjefe1
- Lutheran Satire: "Teaching the faith by making fun of stuff."
M
- M3RKMUS1C
- Maggie Mae Fish
- Malinda Kathleen Reese
- Malukah
- MangaKamen
- Man on the Internet
- Manny MUA: Make-up artist and influencer. Known for the (in)famous original Dramaggedon scandal in 2018 which also involved Jeffree Star.
- Marble Hornets
- Marcel Vos
- Mark Rober
- MasakoTeam
- Masahiro Sakurai on Creating Games
- Ma Star Media
- Matt McMuscles
- Matthew McCleskey
- Mattwo
- MaximBady
- Maxmoefoe
- Meinos Kaen
- MeatCanyon
- Michael Reeves
- Mike BurnFire and Zach Hazard
- The Miley And Mandy Show, a series of (usually) random and silly videos posted and starring Disney Channel star Miley Cyrus and her friend, then-current backup dancer Mandy Jiroux.
- Miniminter: Co-founder of the Sidemen.
- Miniminuteman
- Minus World (YouTube): A group of Nintendo YouTubers.
- MinutePhysics
- Miracle of Sound
- Miss Fame
- Mitten Squad
- Miz Cracker
- ML Lanzillotta
- MonteFjanton
- Movies with Mikey
- MrBallen
- MrBeast
- Mia Mulder
- Munecat
- Muppet Viral Videos, made by the actual Muppet Studios.
- MxR
N
- Nakey Jakey
- TheNamelessDoll
- nana825763
- NateWantsToBattle
- Natsuki Hanae: Japanese voice actor who does Let's Plays with fellow voice actors.
- Nick Crowley: Documentary YouTuber who focuses on horror and dark mysteries.
- Night Mind: Videos about online horror content, such as analysis of more complicated Alternate Reality Games and storylines.
- Nijisanji
- Nikita Dragun: Popular transgender make-up guru. Often involved in drama and scandal.
- Nina Bonina Brown
- Ninja Sex Party
- Noah Caldwell-Gervais: Lengthy, in-depth analysis videos on various video games and franchises- also occasional travelogues.
- Nominal Dingus
- No Parking Berry
- Noodle
- The Nostalgia Critic, along with Doug Walker's Five Second Movies
- Numberphile
O
- Onevilage
- Ordinary Things
- Ozzy Man Reviews
- Outside Xbox and spinoff channel Outside Xtra
- Overly Sarcastic Productions
- OverSimplified
P
- Pandora Boxx
- Pastra
- Patrick (H) Willems
- PeanutButterGamer
- Peter Hollens
- Phelous
- Philosophy Tube: High production-value videos on philosophy from a leftist viewpoint.
- Phil's Pulls
- Pikasprey: Two channels - a gaming channel, and a review/commentary channel.
- Plainrock124
- Polaris and most of its affiliates call YouTube home, including several notable gaming media producers.
- Pokémon Talk
- Potter Puppet Pals: Definer of "animutation".
- Press Heart To Continue
- Primm's Hood Cinema
- ProJared
- The Proper People: Urban exploration duo.
- ProtonJon
- ProZD
- Pyrocynical
Q
R
- Rabtoons
- RackaRacka
- RadicalSoda
- Radio Tapok
- Rage Select
- Franchesca Ramsey, a.k.a. Chescaleigh
- Rank10YGO
- RDCworld1
- React Media: Production company of React, MyMusic, and Reverse Ratings founded by the Fine Brothers.
- The Reads with Scar & Toph
- RecD
- RedLetterMedia
- RetroShock
- rSlash
- The Remarkable Journey of Higgins von Higgings
- Rubber Ross
- Ryan George: Does comedy sketches, as well as being a voiceover for ScreenRant.
- Ryan ToysReview, the poster child of children's toy review and YouTube channels in general.
- RV Maika
S
- Sabaton History: Documentary series hosted by Indy Neidell about the historical events behind Sabaton's Horrible History Metal.
- Saberspark: Animation reviews and esays.
- Saltydkdan
- Sam and Colby
- Sam & Mickey, two women who create adult-targeted Barbie Stop Motion comedies.
- Sam O'Nella Academy
- Sarah Z
- seinfeldspitstain
- Scammer Revolts: YouTube scambaiting channel.
- Schaffrillas Productions
- SciShow: Edutainment by Vlogbrothers. Hank and other people talk about science topics.
- Scott The Woz
- Seth Skorkowsky: Reviews Call of Cthulhu and other resources of horror RPGs.
- Sexplanations, a sex-positive education channel hosted by Dr. Lindsey Doe.
- SF Debris: Science fiction reviews that focus on Star Trek.
- Sgt Ducky
- Shane Dawson: Sketch comedy, acting as all his characters. Also known for conspiracy videos.
- The Shark Puppet
- Sheamus: Host and creator of the lifestyle and fitness channel Celtic Warrior Workouts.
- Shimajiro: A Wonderful Adventure (the English dub of Shimajiro no Wao! and several Kodomo Challenge segments is a YouTube exclusive. The Indonesian dub is also this.)
- SiIvaGunner: A parody of YouTube channels who upload Game Music.
- Sidemen: British group of seven YouTube-based Internet personalities who started out as merely Let's Players before becoming a comedic entertainment group with a powerhouse Internet brand.
- The Slender Man Mythos. Most of the video-based stories are YouTube.
- The Slow Mo Guys: Gavin Free and his buddy Dan Gruchy shoot things in slow motion. Their most famous video is popping a gigantic water balloon and it got over 170 million views. The channel is so notable that they've done sponsored collaborations and YouTube funded a bigger-budget series of their videos. Ironically, Gavin started the channel specifically so he could work for Rooster Teeth, and its popularity has surpassed all of Rooster Teeth's other channels combined.
- Smooth McGroove
- SNES drunk
- snorty
- Solid jj
- SomecallmeJohnny
- Sorrow TV
- Space Ice
- Spaceships and Psychics: Does Youtube videos about Science Fiction and Science Fantasy Tabletop Games alongside text articles.
- Spangooner
- The Spiffing Brit
- The Spoony Experiment: Started on YouTube before being affiliated with Channel Awesome.
- Sr. Pelo
- Luca Stricagnoli
- Stalker2k7
- State Of The Arc
- Steve 1989 MRE Info
- The Stupendium
- Sugarzaza
- Summoning Salt: Documentary-style videos about the history of Speedrunning.
- Sunny V 2: Internet commentator.
- Super Carlin Brothers: Ben and Jay (Jonathan) Carlin, Sibling Team. Discusses Harry Potter, Disney, Pixar and / or Star Wars.
- Supermarioglitchy4, otherwise known as SMG4
- SuperMarioLogan
- SuperMega: Ryan Magee and Matt Watson play video games while providing commentary usually filled with vulgarity and innuendo.
T
- Tana Mongeau: Originally became popular for her outrageous 'Story Time' style videos. Now known for her various scandals and relationships.
- Tantacrul
- Tales Of Mere Existence
- Tats Tops Videos
- Tati Westbrook: a beauty guru originally known as GlamLifeGuru.
- Tay Zonday
- TBJZL: Co-founder of the Sidemen.
- Te Lo Resumo Así Nomás
- Techmoan: British retro tech YouTuber who focuses mostly on vintage audio/video equipment.
- Team Four Star: Creators of several Abridged Series, most famously Dragon Ball Z Abridged.
- Team Starkid: A theatre troupe from the University of Michigan, specializing in musical comedies, most often parodies, which they upload on YouTube.
- Team Starkid Members: The various individual team members.
- Tenille Dashwood: Host and creator of the cooking, travel, and lifestyle channel, Taste of Tenille.
- TektonTV
- Tess Masazza
- Testeur Alpha
- TheParryGod: Producer of high-quality S2FM Half-Life short films.
- The Theorizer
- The Urban Rescue Ranch
- Thought Slime
- Timothée Chalamet: Before he became known as an actor, he was a YouTuber when he was 15 under the name ModdedController360 where he showed off his custom-painted Xbox controllers. The Game Awards referenced this in the 2023 when he came out to present the Game of the Year award for that year.
- Tim Tom
- Tobuscus
- TomSka
- Tonkatsu Sinclair, an Affectionate Parody of a Virtual YouTuber.
- Totally Not Mark
- Transformers: The Basics
- TREY the Explainer: Videos discussing myths and truths about science, particularly biology and paleontology.
- Tribe Twelve
- Triple-Q: Mashup musician
- Trisha Paytas: Known for her dramatic vlogs and her 'Mukbang' videos. (In)famous for creating scandals and being a self-confessed troll.
- Trixie Mattel
- True Facts: A series of videos by comedian Ze Frank. He talks about various animals in a humorous manner while doing a Morgan Freeman impression.
- The Try Guys: Comedy web video series.
- Tucker Budzyn
- twelthofadime, a comedy sketch channel spinoff of Makemebad35 hosted by Kyle McIlrath Adams.
- Twisted Translations: Malinda Kathleen Reese performs Translation Train Wreck versions of various songs.
- TwoSet Violin: A pair of Asian-Australian classical violinists who offer humorous sketches and commentary on the work of a classical musician, critiques of musical performances in popular media and musical challenges.
U
V
- Vasi Birchwood
- Vester And Friends
- VGMyths
- Vic Berger
- Vikkstar123: Member of the Sidemen.
- VShojo
- Vlogbrothers: Hank Green and John Green started a vlogging project:
- Mental Floss (yes, based on that Mental Floss - John wrote for them for his first job), in which the brothers talk about trivia.
- Hank's Channel: Hank's own personal channel where he posts anything that doesn't fit anywhere else.
- The Miracle of Swindon Town, in which John plays the Fifa series while talking about stuff and making up backstories for his players.
- VibingLeaf
- The Virtual Reality Show: A show about various virtual reality topics all while being filmed in VR.
W
- Wambu
- Wartime Stories
- The Watchers
- Whatifalthist
- Wholesome Girlfriend ASMR
- Willam Belli
- The Winglet
- Wojti 2000
- World According To Jon: Opinions on nearly everything.
- Worthikids
- wroetoshaw (W2S): Member of the Sidemen.
X
Y
- YidLife Crisis
- Yong Yea: Creates videos relating to the video game industry.
- Yotobi: Former Italian internet reviewer, currently makes a video format loosely based on freestanding comedy.
- YouTube Rewind, YouTube's former annual video series that summarizes each year in internet culture.
- Your Favorite Martian: Animated music video series.
- Yu-Gi-Oh! The Abridged Series: Was likely the first fandubbed series to have episodes pulled off the site for copyright infringement.
- The Young Bucks: Host and creators of Being the Elite.
- Yuhua Hamasaki
- Yung Junko
- Yuriofwind
Z
- Karolina Żebrowska
- Zack Ryder: Creator and star of Z! True Long Island Story.
- Zerkaa: Co-founder of the Sidemen.
- ZeroLenny: Dark Souls challenge runner.
- Zero9teen
- Zero Punctuation
- Zigmenthotep: Some weirdo on the internet who reviews (mostly obscure) Tabletop RPGs.