The Courier and Companionsnote The Courier, Arcade Israel Gannon, Craig Boone, Raul Alfonso Tejada, Rose of Sharon Cassidy, Lilian Marie Bowen, Veronica Renata Santangelo, ED-E, Rex
New California Republicnote President Aaron Kimball, Ambassador Dennis Crocker, Office of Science and Industry, General Lee Oliver, Colonel James Hsu, Colonel Cassandra Moore, Major Dhatri, Lieutenant Carrie Boyd, Cpt. Ronald Curtis, Sgt. Daniel Contreras, Corporal William Farber, Pvt. Christina Morales, Major Joseph Polatli, Quartermaster Carl Mayes, Tech Sergeant Reyes, Dr. Alex Richards, Pvt. James Sexton, Major Knight, First Sergeant Astor, Pvt. Kyle Edwards, Chief Hanlon, the NCR Rangers, First Recon, The Misfits, Captain Gilles, Lieutenant Markland, The Arms Merchant, Captain Parker, Private Halford, Colonel Royez
Caesar's Legionnote Caesar, Lucius, Vulpes Inculta, Antony, Otho, Siri, Melody, Legate Lanius, Aurelius of Phoenix, Decanus Severus, Canyon Runner, Cursor Lucullus, Silus, Picus, Dead Sea, Alexus, Karl, Cato Hostilius, Gaius Magnus
The Stripnote Victor, Mr. New Vegas, Jane, The Chairmen, Benny, Swank, Tommy Torini, Aces Theater Performers, Yes Man, The White Glove Society, Heck and Ted Gunderson, The Omertas and Contractors, Gomorrah Prostitutes, Sarah Weintraub, Michael Angelo
Settlementsnote Goodsprings (Doc Mitchell, Trudy, Sunny Smiles, Chet), Primm (Johnson and Ruby Nash, Deputy Beagle, Primm Slim), Nipton, Novac (Jeannie May Crawford, No-Bark Noonan, Ada Straus, Old Lady Gibson), 188 Trading Post (The Forecaster, Alexander), Aerotech Office Park (Keith, Frank Wheathers), Freeside (James and Francine Garret, Caleb McCaffery, Fisto, Rotface, Mick and Ralph, Dixon, Genaro, Santiago, Lady Jane, Grecks, Beatrix Russell, Old Ben, Orris), Westside (Red Lucy, Mean Sonofabitch, Marco, Pretty Sarah, Sweetie, Maude, Jimmy, Dermot and Saint James), North Vegas Square (Crandon, Jules), Jacobstown (Keene, Doc Henry, Calamity)
Other Factionsnote The Boomers, Bright Brotherhood, Brotherhood of Steel, Enclave Remnants, The Fiends, Followers of the Apocalypse, Great Khans, The Kings, Powder Gangers, the Van Graffs, Crimson Caravans, State of Utobitha, Minor Gangs
Other Charactersnote Davison, Festus, Malcolm Holmes, Allen Marks, Tomas and Jacklyn, Logan, Sammy and Pauline Wins, Miss Fortune
Dead Money Charactersnote Ghost People, Dog/God, Christine Royce, Dean Domino, Father Elijah, Vera Keyes, Frederick Sinclair
Honest Hearts Charactersnote Randall Dean Clark, Follows-Chalk, Waking Cloud, Joshua Graham, Daniel, Salt-Upon-Wounds, The White Legs, Happy Trails Caravan Company (Jed Masterson, Stella, Ricky)
Old World Blues Charactersnote The Think Tank, The Inhabitants of the Sink, The Stealth Suit Mark II, Dr. Mobius, Roxie, The Courier's Brain, Lobotomites