“DagCoin: a cryptocurrency without blocks”; in an entirely different direction, Bitcoin-NG splits blocks from mining (Bitcoin is just the first, not necessarily the universally ideal. We’re in a Cambrian explosion of financial cryptography and should be open to new approaches.)
Do No Harm, Marsh (elegantly written and moving neurosurgeon memoir on the theme of iatrogenics; I did disagree with his comments on the cost-benefit of operating in one case, though)
Hanamonogatari/Tsukimonogatari (disappointments, coming after Second Season. Neither had a particularly compelling story—Hana was interesting but could not support that many episodes and Tsuki’s ending with Tadatsuru was bafflingly idiotic and incompetent an anticlimax with apparently the whole thing being mostly wasted time on developing yet another one of the worst & overused archetypes in anime)
This page is a changelog for Gwern.net: a monthly reverse chronological list of recent major writings/changes/additions.
Following my writing can be a little difficult because it is often so incremental. So every month, in addition to my regular /r/Gwern subreddit submissions, I write up reasonably-interesting changes and send it out to the mailing list in addition to a compilation of links & reviews (archives).
A subreddit for posting links of interest and also for announcing updates to gwern.net (which can be used as a RSS feed). Submissions are categorized similar to the monthly newsletter and typically will be collated there.
“Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci”, D J. Smith, V. Escott-Price, G. Davies, M. E S. Bailey, L. Colodro-Conde, J. Ward, A. Vedernikov, R. Marioni, B. Cullen, D. Lyall, S. P Hagenaars, D. C M. Liewald, M. Luciano, C. R Gale, S. J Ritchie, C. Hayward, B. Nicholl, B. Bulik-Sullivan, M. Adams, B. Couvy-Duchesne, N. Graham, D. Mackay, J. Evans, B. H Smith, D. J Porteous, S. E Medland, N. G Martin, P. Holmans, A. M McIntosh, J. P Pell, I. J Deary, M. C O'Donovan, (2016):
Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the UK Biobank cohort, 6659 participants from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and 8687 participants from a QIMR (Queensland Institute of Medical Research) Berghofer Medical Research Institute (QIMR) cohort. All participants were assessed using the same neuroticism instrument, the Eysenck Personality Questionnaire-Revised (EPQ-R-S) Short Form’s Neuroticism scale. We found a single-nucleotide polymorphism-based heritability estimate for neuroticism of ~15% (s.e.=0.7%). Meta-analysis identified nine novel loci associated with neuroticism. The strongest evidence for association was at a locus on chromosome 8 (P=1.5 × 10−15) spanning 4 Mb and containing at least 36 genes. Other associated loci included interesting candidate genes on chromosome 1 (GRIK3 (glutamate receptor ionotropic kainate 3)), chromosome 4 (KLHL2 (Kelch-like protein 2)), chromosome 17 (CRHR1 (corticotropin-releasing hormone receptor 1) and MAPT (microtubule-associated protein Tau)) and on chromosome 18 (CELF4 (CUGBP elav-like family member 4)). We found no evidence for genetic differences in the common allelic architecture of neuroticism by sex. By comparing our findings with those of the Psychiatric Genetics Consortia, we identified a strong genetic correlation between neuroticism and MDD and a less strong but significant genetic correlation with schizophrenia, although not with bipolar disorder. Polygenic risk scores derived from the primary UK Biobank sample captured ~1% of the variance in neuroticism in the GS:SFHS and QIMR samples, although most of the genome-wide significant alleles identified within a UK Biobank-only GWAS of neuroticism were not independently replicated within these cohorts. The identification of nine novel neuroticism-associated loci will drive forward future work on the neurobiology of neuroticism and related phenotypes.
Chernoff faces, invented by Herman Chernoff in 1973, display multivariate data in the shape of a human face. The individual parts, such as eyes, ears, mouth and nose represent values of the variables by their shape, size, placement and orientation. The idea behind using faces is that humans easily recognize faces and notice small changes without difficulty. Chernoff faces handle each variable differently. Because the features of the faces vary in perceived importance, the way in which variables are mapped to the features should be carefully chosen.
In software engineering, rubber duck debugging is a method of debugging code. The name is a reference to a story in the book The Pragmatic Programmer in which a programmer would carry around a rubber duck and debug their code by forcing themselves to explain it, line-by-line, to the duck. Many other terms exist for this technique, often involving different (usually) inanimate objects, or pets such as a dog or a cat.
Intense meditation practices help to achieve a harmony between body and mind. Meditation practices influence brain functions, induce various intrinsic neural plasticity events, modulate autonomic, metabolic, endocrine, and immune functions and thus mediate global regulatory changes in various behavioral states including sleep. This brief review focuses on the effect of meditation as a self regulatory phenomenon on sleep.
A Perfect Vacuum is a 1971 book by Polish author Stanisław Lem, the largest and best known collection of Stanislaw Lem's fictitious criticism of nonexisting books. It was translated into English by Michael Kandel. Some of the reviews remind the reader of drafts of his science fiction novels, some read like philosophical pieces across scientific topics, from cosmology to the pervasiveness of computers, finally others satirize and parody everything from the nouveau roman to pornography, Ulysses, authorless writing, and Dostoevsky.
The Party: The Secret World of China's Communist Rulers is a book written by Richard McGregor, a former bureau chief of the Financial Times in China. It was published by Penguin Books on June 25, 2010. The traditional Chinese version 《中國共產黨不可說的秘密》 was published by Linking Publishing Company (聯經出版) in Taiwan, Republic of China on September 16, 2011.
Subscription page for the monthly gwern.net newsletter. There are monthly updates, which will include summaries of projects I’ve worked on that month (the same as the changelog), collations of links or discussions from my subreddit, and book/movie reviews. You can also browse the archives since December 2013.
Newsletter tag: archive of all issues back to 2013 for the gwern.net newsletter (monthly updates, which will include summaries of projects I’ve worked on that month (the same as the changelog), collations of links or discussions from my subreddit, and book/movie reviews.)