This is a summary of the revision-history RSS feed, overlapping with Changelog & including material from /r/gwern/. This broadcast has been brought to you by Def-Con Owl Traps (kills owls dead!) and my donors on Gratipay.
This page is a changelog for Gwern.net: a monthly reverse chronological list of recent major writings/changes/additions.
Following my writing can be a little difficult because it is often so incremental. So every month, in addition to my regular /r/Gwern subreddit submissions, I write up reasonably-interesting changes and send it out to the mailing list in addition to a compilation of links & reviews (archives).
A subreddit for posting links of interest and also for announcing updates to gwern.net (which can be used as a RSS feed). Submissions are categorized similar to the monthly newsletter and typically will be collated there.
Background: Next generation sequencing (NGS) is now being used for detecting chromosomal abnormalities in blastocyst trophectoderm (TE) cells from in vitro fertilized embryos. However, few data are available regarding the clinical outcome, which provides vital reference for further application of the methodology. Here, we present a clinical evaluation of NGS-based preimplantation genetic diagnosis/screening (PGD/PGS) compared with single nucleotide polymorphism (SNP) array-based PGD/PGS as a control.
Results: A total of 395 couples participated. They were carriers of either translocation or inversion mutations, or were patients with recurrent miscarriage and/or advanced maternal age. A total of 1,512 blastocysts were biopsied on D5 after fertilization, with 1,058 blastocysts set aside for SNP array testing and 454 blastocysts for NGS testing. In the NGS cycles group, the implantation, clinical pregnancy and miscarriage rates were 52.6% (60⁄114), 61.3% (49⁄80) and 14.3% (7⁄49), respectively. In the SNP array cycles group, the implantation, clinical pregnancy and miscarriage rates were 47.6% (139⁄292), 56.7% (115⁄203) and 14.8% (17⁄115), respectively. The outcome measures of both the NGS and SNP array cycles were the same with insignificant differences. There were 150 blastocysts that underwent both NGS and SNP array analysis, of which seven blastocysts were found with inconsistent signals. All other signals obtained from NGS analysis were confirmed to be accurate by validation with qPCR. The relative copy number of mitochondrial DNA (mtDNA) for each blastocyst that underwent NGS testing was evaluated, and a significant difference was found between the copy number of mtDNA for the euploid and the chromosomally abnormal blastocysts. So far, out of 42 ongoing pregnancies, 24 babies were born in NGS cycles; all of these babies are healthy and free of any developmental problems.
Conclusions: This study provides the first evaluation of the clinical outcomes of NGS-based pre-implantation genetic diagnosis/screening, and shows the reliability of this method in a clinical and array-based laboratory setting. NGS provides an accurate approach to detect embryonic imbalanced segmental rearrangements, to avoid the potential risks of false signals from SNP array in this study. [Keywords: preimplantation genetic diagnosis/screening, next generation sequencing, blastocyst, cryopreserved embryo transfer, clinical outcome]
Forecasting technological progress is of great interest to engineers, policy makers, and private investors. Several models have been proposed for predicting technological improvement, but how well do these models perform? An early hypothesis made by Theodore Wright in 1936 is that cost decreases as a power law of cumulative production. An alternative hypothesis is Moore’s law, which can be generalized to say that technologies improve exponentially with time. Other alternatives were proposed by Goddard, Sinclair et al., and Nordhaus. These hypotheses have not previously been rigorously tested. Using a new database on the cost and production of 62 different technologies, which is the most expansive of its kind, we test the ability of six different postulated laws to predict future costs. Our approach involves hindcasting and developing a statistical model to rank the performance of the postulated laws. Wright’s law produces the best forecasts, but Moore’s law is not far behind. We discover a previously unobserved regularity that production tends to increase exponentially. A combination of an exponential decrease in cost and an exponential increase in production would make Moore’s law and Wright’s law indistinguishable, as originally pointed out by Sahal. We show for the first time that these regularities are observed in data to such a degree that the performance of these two laws is nearly the same. Our results show that technological progress is forecastable, with the square root of the logarithmic error growing linearly with the forecasting horizon at a typical rate of 2.5% per year. These results have implications for theories of technological change, and assessments of candidate technologies and policies for climate change mitigation.
The Fractal Prince is the second science fiction novel by Hannu Rajaniemi and the second novel to feature the post-human gentleman thief Jean le Flambeur. It was published in Britain by Gollancz in September 2012, and by Tor in the same year in the US. The novel is the second in the trilogy, following The Quantum Thief (2010) and preceding The Causal Angel (2014).
The Causal Angel is the third science fiction novel by Hannu Rajaniemi featuring the protagonist Jean le Flambeur. It was published in July 2014 by Gollancz in the UK and by Tor in the US. The novel is the finale of a trilogy. The previous novels in the series are The Quantum Thief (2010) and The Fractal Prince (2012).
Hozuki's Coolheadedness is a Japanese manga series written and illustrated by Natsumi Eguchi. The plot revolves around Hozuki, a demon who works for the King and Head Judge of Hell. It was serialized by Kodansha in the magazine Weekly Morning between March 2011 and January 2020, with chapters collected in thirty tankōbon volumes. The manga was adapted into a television anime series; Wit Studio produced the first season in 2014, and Studio Deen was responsible for a second season in 2017–2018. The former studio also produced three original animation DVDs (OADs) in 2015, while the latter produced one OAD in 2017, and Pine Jam produced three more OVAs in 2019 and 2020.
Futakoi Alternative is a Japanese anime television series created by character designer Mutsumi Sasaki and planner & scenario writer Hina Futaba. The series was produced by MediaWorks, King Records, Lantis and Yomiko Advertising and animated by Feel, Studio Flag and Ufotable. It ran for 13 episodes from 7 April 2005 to 30 June 2005. The show features many of the characters from the original Futakoi, though the story and settings are completely different. A manga adaptation of the show is illustrated by Kanao Araki.
Subscription page for the monthly gwern.net newsletter. There are monthly updates, which will include summaries of projects I’ve worked on that month (the same as the changelog), collations of links or discussions from my subreddit, and book/movie reviews. You can also browse the archives since December 2013.
Newsletter tag: archive of all issues back to 2013 for the gwern.net newsletter (monthly updates, which will include summaries of projects I’ve worked on that month (the same as the changelog), collations of links or discussions from my subreddit, and book/movie reviews.)